大唾液腺超声可代替闪烁摄影诊断原发干燥综合征
发表者：智良
日期：2015-03-04
浏览次数：137
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摘要:目的：研究以大唾液腺超声检查代替唾液腺闪烁摄影(sSC)的改良原发性干燥综合征(pSS)美欧分类标准(AEC)的诊断准确度。
方法：对190名研究对象进行评估，诊断其是否患有pSS，诊断方法包括对唾液腺进行超声检查(US)等。判断三种分别包括五项诊断标准的不同的pSS诊断组合的诊断准确度。每一诊断组合均包括四项诊断标准(即：眼部症状、口腔症状、Schirmer-I试验和抗SS-A自身抗体)及以下三者之一：US (US组合)、sSC (sSC组合)或活检(活检组合)。计算受试者工作特征曲线下面积(ROC-AUC)以评估每一诊断组合的诊断准确度。
结果：在总共190名受试对象中，有140名患者符合AEC标准被诊断为患有pSS，其余50名排除pSS诊断。这140名pSS患者中，129人US评分为阳性(占92%)，123人sSC为阳性(占88%)，93人活检结果阳性(66%)。另外，这140名pSS患者中，共分别有88人(63%)、85人(61%)及71人(51%)符合US组合、sSC组合及活检组合诊断标准，而非pSS患者组则没有一人符合上述任一诊断组合。与AEC标准相比，这三种诊断组合的诊断准确度均提高或者相似[US组合的AUC-ROC (s.e.)为0.99 (0.00)，sSC组合的为0.98 (0.00)，活检组合的为0.97 (0.00)]。
结论：对大唾液腺进行US检查或许可以代替AEC标准中的sSC检查。
附原文: Objective. To test the diagnostic accuracy of modified American_European classification criteria (AEC) for primary SS (pSS) by replacing sialoscintigraphy (sSC) with ultrasonography of the major salivary glands. Methods. One hundred and ninety subjects were evaluated for the diagnosis of pSS, including US of the salivary glands. We tested the diagnostic accuracy of the three different sets of five diagnostic criteria for pSS. Each set combined these four criteria (ocular symptoms, oral symptoms, Schirmer-I test and auto-SS-A antibody) and one of the following: US (US set), sSC (sSC set) or biopsy (Biopsy set). The area under the receiver operating characteristics curve (AUC-ROC) was used to evaluate the diagnostic accuracy of each set of criteria.Results. Out of 190 subjects examined, 140 subjects fulfilled the AEC for the diagnosis of pSS, whereas 50 subjects were classified as non-pSS subjects. US score was positive in 129 (92%), sSC in 123 (88%) and biopsy in 93 (66%) of 140 pSS patients. Among 140 patients with pSS, 88 (63%) patients fulfilled the criteria of the US set, 85 (61%) patients of the sSC set and 71 (51%) patients of the Biopsy set. None of the subjects from the non-pSS group fulfilled any of the sets of criteria. Diagnostic accuracy of each of the three sets of criteria was high and similar [AUC-ROC (S.E.) for the US set was 0.99 (0.00), followed by the sSC set at 0.98 (0.00) and the Biopsy set at 0.97 (0.00)].Conclusion. US finding of major salivary gland involvement could replace sSC in AEC for the diagnosis of pSS.
引自:Milic V, Petrovic R, Boricic I, et al. Ultrasonography of major salivary glands could be an alternative tool to sialoscintigraphy in the American-European classification criteria for primary Sjogren's syndrome. Rheumatology (Oxford). 2012; 51(6): 1081-1085. （注：干燥综合症病人或亲属可加QQ群交流，群号： 118194945 ，本网站站长私人微信号： ssgzz88 ）
方法：对190名研究对象进行评估，诊断其是否患有pSS，诊断方法包括对唾液腺进行超声检查(US)等。判断三种分别包括五项诊断标准的不同的pSS诊断组合的诊断准确度。每一诊断组合均包括四项诊断标准(即：眼部症状、口腔症状、Schirmer-I试验和抗SS-A自身抗体)及以下三者之一：US (US组合)、sSC (sSC组合)或活检(活检组合)。计算受试者工作特征曲线下面积(ROC-AUC)以评估每一诊断组合的诊断准确度。
结果：在总共190名受试对象中，有140名患者符合AEC标准被诊断为患有pSS，其余50名排除pSS诊断。这140名pSS患者中，129人US评分为阳性(占92%)，123人sSC为阳性(占88%)，93人活检结果阳性(66%)。另外，这140名pSS患者中，共分别有88人(63%)、85人(61%)及71人(51%)符合US组合、sSC组合及活检组合诊断标准，而非pSS患者组则没有一人符合上述任一诊断组合。与AEC标准相比，这三种诊断组合的诊断准确度均提高或者相似[US组合的AUC-ROC (s.e.)为0.99 (0.00)，sSC组合的为0.98 (0.00)，活检组合的为0.97 (0.00)]。
结论：对大唾液腺进行US检查或许可以代替AEC标准中的sSC检查。
附原文: Objective. To test the diagnostic accuracy of modified American_European classification criteria (AEC) for primary SS (pSS) by replacing sialoscintigraphy (sSC) with ultrasonography of the major salivary glands. Methods. One hundred and ninety subjects were evaluated for the diagnosis of pSS, including US of the salivary glands. We tested the diagnostic accuracy of the three different sets of five diagnostic criteria for pSS. Each set combined these four criteria (ocular symptoms, oral symptoms, Schirmer-I test and auto-SS-A antibody) and one of the following: US (US set), sSC (sSC set) or biopsy (Biopsy set). The area under the receiver operating characteristics curve (AUC-ROC) was used to evaluate the diagnostic accuracy of each set of criteria.Results. Out of 190 subjects examined, 140 subjects fulfilled the AEC for the diagnosis of pSS, whereas 50 subjects were classified as non-pSS subjects. US score was positive in 129 (92%), sSC in 123 (88%) and biopsy in 93 (66%) of 140 pSS patients. Among 140 patients with pSS, 88 (63%) patients fulfilled the criteria of the US set, 85 (61%) patients of the sSC set and 71 (51%) patients of the Biopsy set. None of the subjects from the non-pSS group fulfilled any of the sets of criteria. Diagnostic accuracy of each of the three sets of criteria was high and similar [AUC-ROC (S.E.) for the US set was 0.99 (0.00), followed by the sSC set at 0.98 (0.00) and the Biopsy set at 0.97 (0.00)].Conclusion. US finding of major salivary gland involvement could replace sSC in AEC for the diagnosis of pSS.
引自:Milic V, Petrovic R, Boricic I, et al. Ultrasonography of major salivary glands could be an alternative tool to sialoscintigraphy in the American-European classification criteria for primary Sjogren's syndrome. Rheumatology (Oxford). 2012; 51(6): 1081-1085. （注：干燥综合症病人或亲属可加QQ群交流，群号： 118194945 ，本网站站长私人微信号： ssgzz88 ）